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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۶۷-۶۷
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عنوان انگلیسی Ps-35: Dehydroepiandrosterone Treatment Can Increase GSK3β Phosphorylation in Neural Progenitor Cells
چکیده انگلیسی مقاله Objective: Alzheimer disease (AD) is the most common form of dementia. There is no treatment for this disease, eventually leads to death. In the early stages, the most common symptom is difficulty in remembering recent events. Research indicates that some genetics factors and fracture of special protein in brain produce and deposit aging plaques called amyloid bodies. Studies have shown that any disruption in wnt signaling pathway is associated with AD. One of the important molecules involved in activation or inactivation of this pathway is glycogen syntase kinase3β (GSK3β). The main goal of this study was evaluation of GSK3β phosphorylation by treatment of cells with dihydroepiandrosterone (DHEA) a kind of neurosteroid that decreases in the brain with aging. Materials and Methods: In this study, neural progenitor cells obtained from mouse embryos' brain. Then, these cells were treated with 1μm concentration of DHEA for 48 hours. After 48 hours, the phosphorylation of GSK3β was analyzed by immunocytochemistry. Results: The results of immunochemistry analysis showed that DHEA can increase phosphorylation of GSK3β in neural cells. Conclusion: Overall, we conclude that phosphorylation of GSK3β by DHEA can help to cure AD with activation of Wnt signaling.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/361
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