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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۷۳-۷۳
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عنوان انگلیسی Ps-41: Synergistic Effects of High Doses of Thymoquinone on Tamoxifen Induced Apoptosis in Estrogen Receptor-Negative Cancer Cell Line
چکیده انگلیسی مقاله Objective: The aim of this study was to evaluate Synergistic effect of Thymoquinone (The main active component of black seeds) with Tamoxifen drug on apoptosis of human breast cancer MDA-MB-231 cells (invasive and metastatic human breast cancer cell line, estrogen receptor negative). Materials and Methods: The human breast cancer MDA-MB-231 cells were treated with Tamoxifen (2μM) separately or synergistic with Thymoquinone (150 μM). Morphological conformation of cell death in MDA-MB-231 cells treated by Tamoxifen, Thymoquinone and combination after 48hours was studied by TUNEL assay. The data were analyzed by One-Way ANOVA and Tukey's test. All statistical analyses were done using SPSS software (version19.0). In all cases, p values< 0.05 was considered significant. Results: The data of TUNEL assay in estrogen receptor- negative cancer cells after 48hours treatment were showed that Tamoxifen and Thymoquinone separately or synergistically significant rise of apoptotic index (p< 0.05). This study demonstrates that Thymoquinone anti-tumor action is apart from estrogen pathway and combination of Thymoquinone and Tamoxifen induced extreme apoptotic index in estrogen receptor-negative cancer cells (p< 0.001). So that higher dose of Thymoquinone (150 μM) in combination with lower dose of Tamoxifen (2 μM) induced apoptosis in MDA-MB-231 in a safe manner and free of side effects on normal cells. Conclusion: Thymoquinone procedures through nonestrogen- dependent human breast cancer cells is induced apoptosis. Also, Thymoquinone will increase efficiency of Tamoxifen so we can using very low doses of tamoxifen acceptable amount of tumor cells destroyed. Induced apoptosis, the main mechanism of combination of Thymoquinone and Tamoxifen. These data could bring a new light for the treatment of resistant metastatic breast cancer and also for other type of cancers patients.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/367
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