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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۷۴-۷۴
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عنوان انگلیسی Ps-42: Expression Analysis of Two Stem Cell Markers, RHOXF2 and PIWIL2, in Acute Myeloblastic Leukemia Patients
چکیده انگلیسی مقاله Objective: Acute myeloblastic leukemia (AML), the second most common adults’ leukemia, has a high mortality rate. Therefore, researchers are investigating new treatments for this type of cancer. Cancer stem cell theory states that cancer originates from a subset of cells possess characteristics associated with normal stem cells. Cancer-testis (CT) antigens are a group of tumor associated antigens with restricted expression just in gametogenic tissues but expression in a wide variety of tumors. They are potential targets for cancer immunotherapy. Some of them are stem cell markers. Materials and Methods: We analyzed expression of two previously known stem cell markers and CT antigens, RHOXF2 and PIWIL2, in 40 AML patients versus 10 normal donors by means of real time RT-PCR. Results: RHOXF2 and PIWIL2 showed expression in normal leukocytes. Their expressions were not significantly different in normal and AML patients. Conclusion: As these genes are expressed in normal leukocytes, their potential application in immunotherapy and as tumor biomarker is put under question. Future researches should focus on the expression profiles of so called CT antigens to find those with more testis specific expression.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/368
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