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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۹۶-۹۶
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عنوان انگلیسی Ps-64: Comparison of Immunomodulatory Biomolecules Secretion by Mesenchymal Stem Cells Derived from Murine Lung and Adipose Tissues
چکیده انگلیسی مقاله Objective: Mesenchymal stem cells (MSCs) are a unique subset of progenitor cells and therapeutic stem cell sources for regeneration of damaged tissues. These tissue resident stem cells have a potential to regulate the immune system by secretion of soluble factors including transforming growth factor-β (TGF-β) and nitric oxide (NO). MSCs have been disclosed in lung and adipose tissues but the comparison of adult lung and adipose tissue resident MSC populations is still unclear. In the present study, TGF-β and NO secretion were compared in isolated MSCs from lung and adipose tissues. Materials and Methods: MSCs were isolated from murine lung and adipose tissues and then cultured. Following proliferation, specific differentiation media were added for differential investigations and the expression of a set of surface antigenic proteins, CD73, CD105, CD90, CD34, CD45 and CD11b, were measured and compared in both cell populations. Finally, TGF-β and NO productive levels were assayed and compared in cultured lung-derived MSCs and adipose tissue-derived MSCs populations. Results: Both stem cell populations revealed fibroblastoid morphology with similar size. MSCs from lung and adipose tissues expressed common positive markers; CD73, CD105 and CD90. In addition, they showed low levels of CD34, CD45 and CD11b. The differentiation of adipocyte and osteocyte were detected by two MSC populations. Eventually, no significant difference was statistically found in TGF-β and NO production between lung-derived MSCs and adiposederived MSCs. Conclusion: According to the similarity of lungderived MSCs and adipose tissue-derived MSCs in immunophenotypes and secretions, it is proposed that adipose-derived mesenchymal stem cells could be an alternative stock of stem cells for lung cell therapy and transplantation.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/390
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