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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۹۹-۹۹
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عنوان انگلیسی Ps-67: Production of Electrospun PLA/ Gelatin Scaffold for Skin Tissue Engineering
چکیده انگلیسی مقاله Objective: Repair or replacement of damaged tissues by using tissue engineering technology is considered to be a fine solution for enhanced treatment of different diseases such as skin diseases. Although the nanofibers made of synthetic degradable polymers such as polylactic acid (PLA), have been widely used in the medical field, they do not favor cellular adhesion and proliferation. In order to enhance cell adherence on scaffold and improve biocompatibility, in this study, the surface of PLA scaffold was modified by gelatin. Materials and Methods: For electrospinning, PLA and gelatin were dissolved in hexafluoroisopropanol (HFIP) solvent at varying compositions (PLA:gelatin at 3:7 and 7:3). The properties of the blending nanofiber scaffold were investigated by fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). HandE and Masson̕ s trichrome staining methods were used to histological analysis. Results: Our results showed that the modified PLA/ gelatin 7/3 scaffold is more suitable for fibroblasts attachment and viability than the PLA or gelatin nanofiber alone and fibroblast cultured on PLA/gelatin scaffold is suggested as an alternative way to improve skin wound healing. Conclusion: The present study developed a simple but efficient modification to PLA scaffolds enhancing the potential application of PLA scaffolds in the field of skin tissue engineering applications and wound healing
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/393
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