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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۰۰-۱۰۰
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عنوان انگلیسی Ps-68: The Effect of PLA/CS Scaffold in Improving Skin Wound Healing
چکیده انگلیسی مقاله Objective: Although chronic skin wounds are common, treatment for these disabling conditions remains limited and largely ineffective. In this study, we examined benefits of transplantation of fibroblast cells, cultured on poly lactic acid/chitosan (PLA/CS) scaffold, in wound healing. Materials and Methods: In this study PLA/CS scaffold was prepared by electrospinning method then fibroblast cells were cultured on nanofibrous PLA/CS scaffold then transplanted in rat model. Histological staining methods were used to evaluate cell density, blood vessels and amount of collagen. Results: The macroscopic observations showed wound more quickly improved in scaffold with cells group and slowly improved in control groups. In vivo assessment showed that treatment with fibroblast cell loaded scaffolds significantly promoted blood vessels formation, cell density and amount of collagen in rat compared with the control groups. Conclusion: These results indicated the capacity of nanofibrous PLA/CS scaffold cultured with fibroblast cells to skin wound healing in vivo.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/394
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