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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۰۶-۱۰۶
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عنوان انگلیسی Ps-74: Transplantation of Islet-Like Cell Clusters Derived from Human Dental Pulp Stem Cells Restores Normoglycemia in Diabetic Mice
چکیده انگلیسی مقاله Objective: The success of islet transplantation for diabetes depends on the availability of an adequate number of islets, allogeneic or autologous origin. Post natal stem cells are now considered for the generation of physiologically competent, insulin-producing cells. Materials and Methods: In this investigation, we generate functional islets from stem cells from pulps of human exfoliated deciduous teeth (SHED) and permanent teeth (DPSCs) by using a serum free cocktail of three-step protocol and then compared the yield of generated islet like cell clusters (ICCs) from SHED and DPSCs. We, packed ICCs derived from SHED in immuno- isolatory biocompatible macro capsules and then transplanted into Streptozotocin (STZ) induced diabetic mice. Non diabetic and diabetic controls were run parallel to the experimental diabetic group transplanted with macro capsules with or without islets. Results: We found SHED superior to DPSCs. We observed that STZ diabetic mice alone and those transplanted with empty macro capsules exhibited hyperglycemia throughout the experiment whereas those transplanted with macro capsules containing ICCs restored normoglycemia within 3-4 weeks which persisted for more than 60 days. Conclusion: ICCs derived from SHED upon transplantation to STZ diabetic mice can bring about reversal of experimental diabetes by two ways (i) supply of exogenous insulin secreted by ICCs and (ii) triggering of pancreatic regeneration via paracrine secretions of ICCs. Our results demonstrate for the first time that ICCs derived from SHED could reverse the STZ diabetes in mice without immunosuppression and offer an autologous and non-controversial source of human tissue that could be used for stem cell therapy in diabetes.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/400
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