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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۳۱-۱۳۱
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عنوان انگلیسی Ps-100: Muscle Cells Treated with Hypoxia and Laser In Vitro Can Recruit Mesenchymal Stem Cells through Overexpression of SDF1
چکیده انگلیسی مقاله Objective: The applications of mesenchymal stem cells (MSCs) are still far away for being enlisted in the definitive and routine clinical settings. One of the most challenging problems is their inefficient homing to the desired damaged tissue. Recently, cell-based therapies have focused on novel strategies to solve this problem. Studies showed that stromal derived factor (SDF)-1 chemokine and its receptor, CXC chemokine receptor-4 (CXCR4), have pivotal role to direct homing of MSCs. Moreover, the effects of hypoxia and low level laser based treatments, which are well-known protective phenomenon for increased recruitment, retention and survival of transplanted stem cells at the site of injury have recently taken into consideration. Materials and Methods: Here we evaluated the effects of hypoxic condition and low level laser (He-Ne) treatment on the human cardiomyocytes (hCMs), human skeletal myocytes (hSKMCs) and glioblastoma (as control positive) for expression of SDF-1. The second step was migration assay of MSCs toward these treated cells (hCMs, hSKMCs and glioblastoma); These parameters were analyzed by real-time PCR, western blotting and in vitro transwell migration assay, respectively. Results: Results showed that hypoxia and low level laser treatment on hCMs have had the potential to induce overexpression of SDF-1 and subsequently increase the migration of MSCs toward pre-conditioning cells as compared with control groups. Conclusion: Findings of this study elevate our knowledge about SDF-1/CXCR4 axis as an attractive target pathway to improve the beneficial impacts of homing and MSC-based therapies.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/425
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