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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۳۴-۱۳۴
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عنوان انگلیسی Ps-103: MicroRNAs in Breast Cancer Stem Cells and Their Potential for Breast Cancer Therapy
چکیده انگلیسی مقاله Objective: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide. According to the cancer stem cell hypothesis, breast tumors are hierarchically organized with cancer stem cells (CSCs). Targeting CSCs is of great interest as CSCs are considered to be more resistant to radiotherapy and chemotherapy. The small RNAs, which are called microRNAs (miRNAs), act as endogenous suppressors of gene expression, act as oncogenes or tumor suppressors, and are also thought to be responsible for the dissemination and growth of CSCs. Materials and Methods: Aberrant expression of miRNAs was identified in cancer stem cells. Using stem-loop technology to test for differences in expression of miRNAs in breast cancer stem cells (BCSCs) and the MCF-7 breast cancer cell line; some miRNAs were over-expressed, with levels four times higher in BCSCs than in MCF-7 cells. These miRNAs included, miR-122a, miR-152, miR-212, miR-224, miR-296, miR-31, miR-373 and miR-489. Furthermore, miR- 200a, miR-301, miR-188, miR-21, miR-181d, and miR-29b showed four times lower expression levels in BCSCs compared to MCF-7 cells. Results: Taken together, it has been shown that above mentioned are involved in the proliferation or suppression of breast cancer stem cells. Regulating the expression of one specific miRNA could decrease the tumorinitiating, self-renewal ability of BCSCs or promote differentiation, which provides a promising new direction for clinical cancer therapy. Conclusion: Finally, even though new technologies are emerging to improve the specificity, stability, and efficiency of miRNA delivery and therapy, the final outcomes remain uncertain.To fully reveal the mechanisms of miRNA function and to clinically apply miRNAs to tumor therapy, a substantial amount of further work is needed.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/428
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