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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۵۱-۱۵۱
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عنوان انگلیسی Ps-120: Expression Evaluation of Two Members of DNA Repair System (OGG1 and MTH1) in Patients with Stenosis and In-stent Restenosis
چکیده انگلیسی مقاله Objective: Coronary stenosis is known as one of the major life-threatening factors which is cured with variety of methods like Carotid angioplasty and stenting (CAS). With useful success, coronary restenosis occurred 4-6 months after percutaneous coronary intervention (PCI) still remains as a limitation for this procedure. The causative mechanism is not unraveled, despite all medical advances in order to find molecular basis of the process. Prior studies demonstrated the existence of DNA damages in coronary arteries and peripheral blood mononuclear cells (PBMCs). The aim of this study was to evaluate the expression of two critical members of DNA repair system as OGG1 and MTH1 for the first time. Materials and Methods: Two groups of PBMCs consisted of 20 patients as stenotic group and 20 as patients with in-stent restenosis were purified. After RNA extraction, Real-time PCR was performed for OGG1 and MTH1 with beta actin gene as internal control. Results: Kolmogorov-Smirnov test show normal distribution of data between two groups (p< 0.05). Our Real-time PCR results confirmed the hypothesis that there is an expression difference between stenotic and restenotic patients Conclusion: The study uphold that efficiency of repair system genes can influence the process of stenosis and also restenosis.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/445
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