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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۵۲-۱۵۲
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عنوان انگلیسی Ps-121: Association of XRCC1 Polymorphisms and Haplotype Frequencies with Risk of Developing Atherosclerosis
چکیده انگلیسی مقاله Objective: Coronary artery disease (CAD) is the leading cause of death in all around the world. The main cause of CAD is the atherosclerosis of coronary arteries. Several evidences showed that DNA lesions may trigger CAD development. So, it has been proposed that single nucleotide polymorphisms (SNPs) that decrease DNA repair efficiency may play key roles in individual’s susceptibility to atherosclerosis. One of the most important proteins which plays critical roles in different repair pathways is XRCC1. Two SNPs (Arg194Trp and -77T>C) were reported to affect function and expression of XRCC1, respectively. The aim of this study was to investigate the relationship between these two SNPs and the risk of developing CAD in Iranian population. Materials and Methods: A case-control study was performed with 414 individuals including 207 patients diagnosed with CAD and 207 diagnosed as negative for CAD (control group). All participants were angiographically confirmed. SNPs were identified by the polymerase chain reaction–restriction fragment length polymorphism method. Results: The XRCC1 Trp allele frequency for codon 194 was statistically more pronounced in the case subjects than in controls (OR=2.604, 95% CI=1.506–4.504, p=0.001). Another novel SNP -77T>C revealed protective role in our population through SP1 transcription effect (OR=0.618, 95% CI=0.399–0.960, P=0.032). Conclusion: Taken together, our findings demonstrate a contributory role of XRCC1 SNPs in development of CAD. Furthermore, our results support the role of DNA damage and repair in cardiovascular disease.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/446
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