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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۵۳-۱۵۳
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عنوان انگلیسی Ps-122: Seminal Vesicle Fluid Ameliorates Experimental Autoimmune Encephalomyelitis by Increasing FoxP3 Expression
چکیده انگلیسی مقاله play pivotal role in preventing destructive immunity against auto immune response. These cells show reduced frequency and/or function in multiple sclerosis (MS). Insemination elicits expansion of natural FoxP3+regulatory T-cells pool at female reproductive tissue during mating due to seminal vesicle fluid. Notably, there was a differential recruitment of Foxp3+ regulatory T-cells into different organs with the lowest rate in brain than that of other organs. Such an effect on FoxP3 regulatory T-cells expansion prompted us to investigate effect of intra-CSF administration of seminal vesicle fluid on experimental autoimmune encephalomyelitis (EAE), the animal model for MS. Materials and Methods: The disease was induced in female Lewis rats using guinea pig spinal cord and complete Freund's adjuvant. Seminal vesicles fluid was obtained from freshly slaughtered male rats. The animals treated with seminal vesicle fluid were considered as test group and two groups of rats were used as control in which one group was injected with saline and the second was left without injection. The animals were evaluated for weight loss and clinical signs from day 0 to day 14 after the disease induction. Expression of mRNA for IFN-γ, IL-4, IL-17, and FoxP3 in brain and spinal cord was determined using real-time PCR in which β-actin was used as reference gene. Results: Administration of seminal vesicle fluid led to significant decrease in clinical sign, weight loss, and increase in Foxp3+ regulatory T-cells within brain and spinal cord, comparing with the control groups. Conclusion: Our results suggest that seminal vesicle fluid contains all the required ligands for activation of Foxp3+ regulatory T-cells pool and has anti-inflammatory effect in organs other than reproductive organ.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/447
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