این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۶۱-۱۶۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Ps-130: Anti-Inflammatory Effect of Adipose Derived Stem Cells
چکیده انگلیسی مقاله Objective: Mesenchymal stromal cells (MSCs) are adherent and multipotent progenitor cells that have the capacity to self-renew and can differentiate into cells of several lineages. A wide range of evidences have demonstrated that MSCs have strong immunosuppressive effects on innate and adaptive immunity through various mechanisms. MSCs also have the ability to cause an arrest of cell division in the G0/G1 phase of the cell cycle. As a consequence of division arrest, MSC has been shown to affect, to a variable extent, T and NK cell cytokine secretion and cytotoxicity, as well as B cell maturation and Ab secretion. Materials and Methods: Adipose derived stem cells (ASCs) were obtained from normal adipose tissue, in sterile condition, washed with PBS, cut in to small pieces, digested with collagenase type I and cultured in tissue culture flask containing MDEM 10% FBS. As cells reached passage 3, they were co cultured in two conditions, directly and by using transwell, with peripheral blood lymphocytes (PBLs) stained with Carboxyfluorescein succinimidyl ester (CFSE). The proliferation of CFSE-labeled PBLs was then analyzed by flow cytometry. Results: Adipose derived stem cells caused 2-fold downregulation in CFSE-labeled-PBLs’ proliferation.This result was seen in both direct and indirect cultures. Conclusion: Anti-inflammatory and immunomodulatory effects of adipose derived stem cells can introduce these cells as therapeutic interventions for a variety of immune related disorders.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله
نشانی اینترنتی http://celljournal.org/journal/article/abstract/455
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات