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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۶۳-۱۶۳
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عنوان انگلیسی Ps-132: Odontogenic Differentiation of Bone Marrow Mesenchymal Stem Cell by Low Intensity Ultrasound
چکیده انگلیسی مقاله Objective: Dental disease affects human health and the quality of life of millions worldwide. In this study, the effects of low intensity continuous ultrasound (LICUS) were examined on differentiation of bone marrow mesenchymal stem cells to odontoblasts, the primary cell responsible for dentinogenesis and dentine repair. Materials and Methods: Rat bone marrow mesenchymal stem cells (rBMSCs) were plated in a medium containing fetal bovine serum (FBS) and were cultured to passage 3. The cells divided to 3 groups: ultrasound, differentiation medium and ultrasound + differentiation medium. The cells were subjected to 1 MHz ultrasound at 355 mW/cm-2 . Cell viability, proliferation and odontogenic differentiation were assessed after the treatment with ultrasound. Results: MTT result demonstrated that cells viability and proliferation in ultrasound group was higher than control group (p< 0.05). Gene expression analyses demonstrated significantly increasing in the expression of odontogenic gens in ultrasound + differentiation medium group (p< 0.01). Conclusion: This study suggests that LICUS regulates proliferation and odontogenic differentiation of rBMSCs.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/457
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