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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۷۶-۱۷۶
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عنوان انگلیسی Ps-145: Repair of Bone Osteoporosis in Ovariectomized Rats by Using ZincTreatment
چکیده انگلیسی مقاله Objective: Osteoporosis affects many people in the world and is associated with fractures, pain and disabilities especially for menopausal women so estrogen deficiency may lead to osteoporosis. Zinc (Zn) serves as a cofactor for many metalloenzymes involved in DNA transcription and protein synthesis and its deficiency can lead to such problems as impaired synthesis/secretion of FSH and LH. There are some interests in studies concerning the role of Zn in maintenance of bones. Zn may have a beneficial effects in preventing bone loss. The aim of this study was to investigate the potential effects of Zn treatment in protecting bone loss induced by ovariectomy in adult female rats. Mature female Wistar rats weighing approximately 200 g were selected and ovariectomized. In control group rats were given distilled water and in experimental group were gavaged with Zinc (50 mg/kg). It was administrated for two months. The femur bone of the animals was collected and tissue bone investigated under a light and electron microscope level. Results: The ovariectomized rats showed a significant decrease in bone mass density of femur in comparison with the intact control group. Ovariectomized group not treated by Zn showed disarrangement structure of lamella and uncalcified bone matrix. Administration of Zn reversed bone loss. It prevented destruction of bone tissue and arrangements were observed in the treated group had the same structure with contact rats compared to the ovariectomized group (p< 0.05). Conclusion: Zn prevents structural alternation in bone after osteoporosis. These findings suggest that Zn could have a potential effect as a new treatment for prevention of bone loss in postmenopausal osteoporosis.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/470
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