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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۷۸-۱۷۸
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عنوان انگلیسی Ps-147: Assessment of Midkine Concentration and Anti-Inflammatory Cytokines in Multiple Sclerosis Patients Treated by Interferon Beta
چکیده انگلیسی مقاله Objective: Midkine (MK), also called neurite growthpromoting factor 2 (NEGF2) is a basic heparin-binding growth factor. Inflammatory responses involve the release various mediators. Among these the MK has been known as an effective inducer of oncogenesis, inflammation and restoration of tissues. MK with stimulating effects in inflammatory responses through increasing the leukocytes migration in multiple sclerosis (MS) patients. The aim of this study was to evaluate the concentration of MK which associated to anti-inflammatory cytokines. Materials and Methods: To assess the MK levels and its association with anti-inflammatory cytokines (IL-10 and TGF-β) in multiple sclerosis patients treated by Interferon beta, the serum concentration of these proteins was assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects. Results: Based on our results, the MK concentration in MS patients is lower than healthy controls. Also we observed significant decrease in IL-10, and TGF-β cytokine levels in MS patients. Conclusion: Our results approve a role for MK in inflammatory reactions in MS. In contrast to other animal study which stated MK increase in EAE model of MS, present research indicated that level of MK Serum decreased. This decrement seems to be due to Interferon beta treatment. Further studies need to be done in different MS patients to determine exact concentration of MK in these Patients.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/472
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