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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۸۱-۱۸۱
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عنوان انگلیسی Ps-150: Ring Chromosomes: Do Etiology and Effects Meet ERVs?
چکیده انگلیسی مقاله Objective: In patients with ring chromosomes compatible with life, phenotypic presentations are so complicated that introducing a vindictive rational genetic reason might be impossible. Recent studies highlighted reprogramming approaches might be applicable for correcting ring chromosomes during iPSC (induced pluripotent stem cell) procedures; hence plasticity hypothesis could open new doors in therapeutic era. Analyzing of whole genomes shows that endogenous retroviral elements (ERVs), which make up about 10% of mammalian genomes, are residues of an ancient infection and has been stabled and inherited in a Mendelian manner through generations. Materials and Methods: Searching and alignment of ERV sequences throughout human genome by novel bioinformatics data analysis methods could lead us to develop a new approach for determination of active elements which integrated in critical harbors in genome. Results: This is a theoretical hypothesis. Conclusion: Although few data are available regarding the expression of ERVs in human tissues, we speculate that high frequencies of ERVs copy numbers per genome might be made them as an ideal gene expression candidate in assessment of molecular pathology of chromosomal structural abnormalities especially in patients with ring chromosome disorders. Based on recent data, there are unknown mechanism can be applied by reprogrammed cell to correct some chromosomal aberrations and we suggest that reactivation of ERVs function during reprogramming may facilitate generation of iPS cells without original chromosomal abnormalities.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/475
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