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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۸۲-۱۸۲
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عنوان انگلیسی Ps-151: Influence of Nanoparticles of CdSe:ZnS on Mice Reproductive Systems’ Development
چکیده انگلیسی مقاله Objective: Quantum Dots (QDs) are ideal for development as luminescent probes due to the advantages of broadband excitation, narrow bandwidthemission and photochemical stability. Nevertheless, in vivo cytotoxicity of these nanoparticles has not been highly considered. This study aimed to evaluate the cytotoxicity effect of CdSe:ZnS on male reproductive system development. Materials and Methods: 10, 20 and 40 mg/kg doses of CdSe:ZnS quantum dots were injected to some one month old male mice. Structural and optical properties of quantum dots were studied by X-Ray Diffraction (XRD), Scanning Tunneling Microscopy (STM) and the number of cells in seminiferous tubes of various groups were analyzed using SPSS 16. Results: One month after CdSe:ZnS injection, studies of testis tissue showed a high toxicity of CdSe:ZnS in 20, 40 mg/kg dose followed by a decrease in basement membrane, destruction in interstitial tissue, deformation of seminiferous tubes, and reduction in number of spermatogonia, spermatocytes, spermatides, and matured sperms. Although histological study of epididymis tissue showed no significant effect of quantum dots on morphology and structure of tubule and its covering epithelium, there was a considerable reduction in the lumen sperm mass. Conclusion: This study showed a high toxicity of CdSe:ZnS quantum dots on development of testis tissue, even in lower doses and considering lack of literature review in this field, this study can be an introduction to researches of toxicity effect of quantum dots on development of male reproduction system.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/476
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