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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۹۰-۱۹۰
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عنوان انگلیسی Ps-159: Repairing Effects of Allograft Bone Marrow-Derived Mesenchymal Stem Cells on Liver Fibrosis in Rat
چکیده انگلیسی مقاله Objective: Despite its numerous limitations, liver transplants are the only definite cure for end-stage liver disease. The present study evaluated the hypothesis that intraperitoneally allotransplantation of bone marrowderived mesenchymal stem cells can improve liver fibrosis in an experimental model. Materials and Methods: Eighteen adult Wistar rats were induced liver fibrosis using thioacetamide (30 intraperitoneal injections biweekly) and were divided into three groups. Two groups were intraperitoneally allotransplanted with bone marrow-derived mesenchymal stem cells (106 cells/kg of body weight) 20 days after the last thioacetamide injection. They were euthanized 4 and 6 weeks after transplantation. The last group was selected as control and was euthanized 20 days after the last thioacetamide injection. Liver samples were histopathologically evaluated using Hematoxylin & Eosin staining and Masson’s trichrome staining. Serum concentrations of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, and albumin were compared between groups. Serum parameters were evaluated using one-way ANOVA and LSD post hoc test. Histopathologic scores were analyzed using Mann- Whitney test (SPSS 11.5). P< 0.05 was considered significant. Results: Transplanting bone marrow-derived mesenchymal stem cells improved survival, liver fibrosis and necrosis in the rats with thioacetamide-induced liver fibrosis. Bone marrow-derived mesenchymal stem cells also significantly recovered serum concentrations of alanine aminotransferase after 4 and 6 weeks (98.33±5.20 U/L and 89.67±3.85 U/L, respectively) and albumin after 6 week (2.93±0.12 g/dL) in comparison with control (132.0±17.95 U/L and 3.30±0.08 g/dL, respectively). Conclusion: Allotransplantation of bone marrowderived mesenchymal stem cells could ameliorate thioacetamide- induced liver fibrosis. This provides a novel approach for the treatment of fibrotic liver disease.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/484
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