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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۲-۲
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عنوان انگلیسی Is-4: Clinical MRI Cell Tracking: The First 7 Years
چکیده انگلیسی مقاله Translational cellular imaging is expected to play a key role in evaluating the outcome of clinical trials using stem cells for tissue regenration. In order to facilitate and implement the translation of novel experimental stem cell therapies into the clinic, one needs to be able to monitor the cellular biodistribution non-invasively following administration. Among the different clinically used cellular imaging techniques, 111In oxine scintigraphy is the only FDA-approved method and has been used primarily for imaging of infection and inflammation. Cellular magnetic resonance (MR) imaging, with its superior spatial resolution and excellent soft tissue anatomical detail, is emerging as the technique of choice to monitor in real-time image-guided stem cell delivery, immediate engraftment, and short-term homing. Up until now, 7 clinical MRI cell tracking studies have been published, all using superparamagnetic iron oxide nanoparticles or SPIOs in an off-label fashion. SPIOs are clinically approved and create strong local magnetic field disturbances that spoil the MR signal leading to hypo- or hyperintense contrast. A major setback is that the particles that were being used have been taken off the market, as their primary, FDA-approved indication (liver imaging of Kupffer cells) did not live up to its promise. However, several companies have started manufacturing novel particles, which possibly can also be used for magnetic particle imaging (MPI). Several other cellular imaging techniques are available, some of which are based on reporter genes, e.g. firefly luciferase for bioluminescent imaging, and herpes simplex virus thymidine kinase for positron emission tomography imaging. While the former cannot be used clinically because of physico-optical constraints, the latter has now also entered the clinic.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/769
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