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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۷-۷
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عنوان انگلیسی Is-16: Vertebrate Regeneration and The Immune System
چکیده انگلیسی مقاله Objective: The adult mammalian body does retain the robust repair capacity of embryonic stages. In contrast to the effective regeneration of other vertebrates, the limited restorative capacity of many adult mammalian tissues has been attributed to the loss of adequate cell replacement coupled with persistent inflammation. Materials and Methods: Using genetic manipulation we have investigated the role of growth factors and resident immune cells in the resolution of tissue injury, in both mouse and axolotl, an efficiently regenerating member of the urodele amphibian family. Results: We have uncovered a complex interaction between local repair mechanisms and immune cells, which participate in the removal of necrotic tissue, secrete growth factors that limit inflammation, maintain tolerance and promote progenitor cell-mediated tissue replacement. We have recently discovered an unexpected connection between regenerative processes and immune tolerance. Conclusion: Our work supports the feasibility of improving cardiac regenerative capacity by modulating key signaling pathways controlled by specific components of the immune system, providing new targets for clinical intervention and improving prospects for molecular and cellular combination therapies.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/781
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