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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۸-۸
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عنوان انگلیسی Is-18: The Epithelial to Mesenchymal Transition in Cancer and Organ Degeneration
چکیده انگلیسی مقاله The epithelial to mesenchymal transition (EMT) is required in the embryo for the formation of tissues which cells originate far from their final destination. The EMT endows cells with migratory and invasive properties. However, once the cells reach their destinations the EMT program must be downregulated. As such, the EMT inducers need to be kept silent in the adult to protect epithelial homeostasis and tissue architecture. The reactivation of the EMT programme in the adult promotes cancer progression and organ fibrosis and recent findings indicate that the EMT can also confer stem cell properties. As the EMT was recruited during evolution to define embryonic territories and to control epithelial plasticity, the embryo holds the clues to the molecular and cellular mechanisms operating after its reactivation in the adult, despite the peculiarities associated with different pathological EMTs. I will discuss recent findings using different model systems to show the contribution of the EMT to different pathologies. As such, when activated in cancer, it promotes the delamination of cells from the primary tumour, the first step of the metastatic cascade. On the other hand, the reactivation of the EMT in normal adult epithelial cells leads to development of organ fibrosis. In the kidney, fibrosis is the link between progressive loss of renal function and primary diseases such as glomerulonephritis, diabetes, toxic injury, congenital abnormalities, urinary tract obstruction and chronic rejection of transplanted kidneys. In the context of the reactivation of EMT, I will discuss the design of therapeutic strategies to fight both organ degenerative diseases and one of the most dangerous aspects of cancer, the formation of metastasis.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/783
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