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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۱۳-۱۳
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عنوان انگلیسی Os-4: Bone Tissue Engineering: Progress and Challenges Challenges
چکیده انگلیسی مقاله Regeneration of large bone defects is considered a challenging task by facio-mandibular and orthopedic surgeons. Bone tissue engineering has been viewed as a promise alternative to the conventional use of bone grafts, due to their limitless supply and no disease transmission. In bone tissue engineering, life science as well as engineering is involved to manufacture an appropriate bone construct. Building blocks for engineered constructs include biomaterials, cells, and growth factors. These factors would be applied alone or in combination depending on the nature of bone tissue defects. At the field of bone tissue engineering and regeneration, there are several challenging issues including the optimal cell source, chemical and physical features of materials and vascularization in replaced tissue. Many scientists believed that mesenchymal stem cells would be considered as an ideal cell source for bone tissue engineering owing to their unique properties. These cells could achieve reasonable regeneration in bone hard-to-cure defects if provided with an appropriate biomaterial and bioactive molecules capable of inducing both differentiation and vascularization.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/791
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