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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۱۳-۱۳
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عنوان انگلیسی Os-5: Transplantation of Human Embryonic Stem Cell-Derived Oligodendroglial Progenitors Reduces Disease Symptoms in Experimental Autoimmune
چکیده انگلیسی مقاله Transplantation of embryonic stem cells and progenitors can reduce the disease symptoms in experimental autoimmune encephalomyelitis (EAE). We derived oligodendroglial progenitors (OPs) from human embryonic stem cells (hESC, HES-1), and labeled them with superparamagnetic iron oxide MR contrast agent together with transduction of luciferase. At 1 week following EAE induction, 1×106 cells were transplanted in the ventricles of C57/BL6 mice. The biodistribution and survival patterns were non-invasively monitored by magnetic resonance and bioluminescence imaging, respectively. Cells remained within the cerebroventricular system and most of them had died at 10 days post-transplantation. Surprisingly, EAE mice that received transplanted hESC-OPs showed a significant decrease in neurological symptoms (EDSS = 0.9±0.2; n=12) compared to that of non-transplanted control animals (3.3±0.4; n=12) at day 15 post-transplantation. Histological examination revealed that transplanted hESC-OPs generated TREM2-positive CD45 cells, increased TIMP-1 expression, confined inflammatory cells within the subarachnoid space, and gave rise to higher numbers of Foxp3-positive regulatory T cells in the spinal cord and spleen. Thus, transplantation of hESC-OPs can reduce the disease symptoms in EAE through immunomodulation, which may lead to new treatments of MS based on stem cell therapy.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/792
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