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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۱۶-۱۶
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عنوان انگلیسی Os-11: Cell Therapy in Renal Disorders
چکیده انگلیسی مقاله A current explanation for development of chronic kidney disease (CKD) is the inequality between damaging mechanism and regenerative repair. At present, dialysis and transplantation remain the only cure options. However, there is trust that stem cells and regenerative medicine may provide additional regenerative options for kidney diseases. Such new treatments might involve induction of repair using endogenous or exogenous stem cells or the reprogramming of the organ to reinitiate development. The possibility that stem cells contribute to the repair of glomerular and tubular injure is of great interest for basic and clinical research. Bone marrowderived stem cells (BMSCs) have been implicated in the restore of renal tissues. If BMSCs repopulate injured nephrons directly or act indirectly over a paracrine/ endocrine mechanism remains also controversial. Therapeutic administration of BMSCs in animal models of acute kidney injury (AKI) suggests that a stem cell-based therapy may improve the recovery of both glomerular and tubular compartments. Whereas the therapeutic benefit of hematopoietic stem cells (HSCs) remains in doubt, numerous studies showed a beneficial effect of mesenchymal stem cell (MSCs) administration in models of acute tubular injury and of endothelial progenitors in acute glomerular injury. According these studies, our results as an initial report has shown that intra-renal arterial injection of autologous bone marrow mesenchymal stem cells (BM-MSCs) ameliorates cisplatin-induced AKI in a rhesus M. mulatta monkey model. This provides a tool in order to confirm results obtained in murine experimental studies and they are invaluable tools for evaluating cell transplantation protocols prior to their use in clinical studies. Also, recent studies demonstrate the presence of renal stem cells (RSCs) within the adult kidney that responsible for podocytes turnover and potentially also capable to give rise to proximal tubular epithelium cells. These cells are capable, when injected in animals with AKI, to localize to renal compartments and contribute to regeneration. We review the current literature on the role of stem cells in renal regeneration. Moreover, important points that still need explanation, such as the homing mechanisms of stem cells to injured tissues, the secreted factors underlying the paracrine/endocrine mechanisms and the long-term behavior of in vivo transplanted stem cells, are discussed.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/798
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