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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۱۶-۱۶
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عنوان انگلیسی Os-12: Co-Administration of Glyburide and Aqueous Extract of Parsley Up-Regulated The Diabetes-Damaged Angiogenesis and GLUT I Protein Expression on The Ovaries
چکیده انگلیسی مقاله Objective: Diabetes has been known to decrease follicular growth. Although antihyperglycemic drugs decrease the serum level of glucose, the ovarian tissue impairments as follicular atresia remain unchanged. On the other hand the glucose transporter type I (GLUT I) expression and ovarian cortical angiogenesis play critical role on theca cells endocrine function and follicular growth, respectively. Thus, present study aimed to evaluate protective effects of glyburide and parsley extract on diabetes-induced damages on the ovary. Materials and Methods: Thirty Mature female rats were divided into five (N=6) test and control-sham groups. The test group subdivided into four groups. The experimental diabetes induced in all test groups. the test group I (D), test group II (GLY) received glyburide at dose of 5 mg/kg, test group III (P) received parsley extract at the dose of 2g/kg and the simultaneous administration of parsley and glyburide was performed in last test group (P+GLY). After 30 days, the immunohistochemical and immunofluorescent analyses were performed to estimate the GLUT I distribution and ovarian angiogenesis, respectively. Results: The ovaries from animals in P and P+GLYadministrated group exhibited higher number of GLUT I expressed follicular cells versus other test groups. Interestingly, the follicular cells of diabetic animals exhibited lower GLUT I protein which were accumulated in one apex of the cells. Co-administration of parsley and glyburide significantly (p< 0.05) up-regulated the cortical vessels distribution. Conclusion: Our data suggest that parsley inhibits the diabetes-induced damages both by promoting vascular remodeling and by up-regulating the GLUT I protein expression.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/799
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