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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۱۸-۱۸
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عنوان انگلیسی Os-15: Three-Dimensional Pericardium Sponge Improves Proliferation and Differentiation of Sca-1+ Cells
چکیده انگلیسی مقاله Objective: Cardiovascular diseases hold the highest mortality rate among other illnesses which reveals the significance of current limitations in common therapies. So recently, the role of three-dimensional (3D) scaffolds has been highlighted for heart failure post-myocardial infarction treatment. Natural-based scaffolds which resemble more to the damaged tissue of interest seem to be more suitable for necrotic cardiomyocytes replacement and restoring the damaged extracellular matrix (ECM). Here, we have evaluated the properties and potentials of a novel pericardium-derived scaffold for replacing the myocardium ECM. Materials and Methods: Following the decellularization of human pericardium membrane (PM), a 3D sponge pericardium scaffold (PS) was processed with well-defined architecture and interconnected pores. After physico-chemical and mechanical characterizations; MTS assay, histological and migration assessments and Real time PCR were performed in vitro with human Sca-1+ cardiac progenitor cells (CPCs). Thereafter, in vivo assessments of scaffolds were conducted. Results: In comparison with decellularized pericardium membrane (DPM) and collagen sponge (COL), the migration, survival, proliferation and differentiation of CPCs were enhanced on PS. Histological examination of subcutaneous transplanted scaffolds after one month revealed intensive angiogenesis, neovascularization and cardiomyocyte differentiation in PS. Conclusion: Taken together, three-dimensional pericardium sponge may be considered as a good candidate for myocardial tissue engineering applications.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/802
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