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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۱۸-۱۸
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عنوان انگلیسی Os-16: Enhancer DNA Methylation in Differentiated and Stem Cells
چکیده انگلیسی مقاله Objective: Since the first report about presence of methyl group on some genomic cytosines in 88 years ago there has been a huge effort to decrypt the function of DNA methylation in development, pathogenesis, differentiation and reprogramming. Most of this effort has been focused on specific genomic regions like promoters, CpG islands and gene bodies, and little is known about the role of DNA methylation in other regulatory regions like enhancers. In this study we aim to focus on DNA methylation at enhancer regions of mouse embryonic stem cells and several semi- or fully differentiated cell types and to make a better insight about interaction between other epigenetic marks including histone modifications, transcription and DNA methylation. Materials and Methods: Several GEO datasets including whole-genome single nucleotide bisulfite sequencing DNA methylation maps of different cell types, ChIP-seq data of several histone modifications and protein bindings to the mouse genome in different tissues, and RNA-seq transcriptome and non-coding RNA of the same cell types are being used. We have developed an R program for the analysis to check the position-specific pattern of epigenetic and transcriptome marks around enhancers. Results: We confirm DNA methylation monitors the tissue specific activity of enhancers, in addition to several already identified chromatin marks. Additionally we show new mechanistic interactions between DNA methylation and several histone modifications. Conclusion: Our results highlight new roles for DNA methylation in leading other epigenetic patterns on enhancers. These findings suggest how some part of epigenome of a cell can be inherited to the offsprings during development and differentiation.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/803
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