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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۲۲-۲۲
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عنوان انگلیسی Ps-4: Application of Oncolytic Reovirus in Breast Cancer Treatment
چکیده انگلیسی مقاله Objective: Cancer is a life-threatening disease that characterized by uncontrolled cell division. Despite modern techniques in diagnosis and therapy, breast cancer is still causing high mortality among women. The use of oncolytic viruses such as Reovirus has received attention recently and currently being used in clinical trials. Reovirus destroys cancer cells with an activated Ras signaling pathway, without damaging healthy human cells. Materials and Methods: Oncolytic effects of reovirus were explored in a highly malignant and invasive model of breast cancer cells. MTT assay was applied for investigation of optimum dosage of virus for next experiments. Results: MTT results showed that the optimum dosage of reovirus was obtained as 4.16 μl/30000 cells that has been used in virus infection. Syncytia formation and necrosis were observed 24 hours after infection using optimum virus dosage in cancer cells culture compared to normal cells culture. Conclusion: These results indicate that reovirus remarkably induce apoptosis in breast cancer cells in vitro and could be a potential tool for targeted cancer therapy in treatment of breast cancer.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/810
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