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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۲۲-۲۲
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عنوان انگلیسی Ps-5: Dose Hyperprolactinemia Induce Reactive Oxygen Species (ROS) Generation in The Testis of Adult Male Mice?
چکیده انگلیسی مقاله Objective: In recent years, the generation of reactive oxygen species (ROS) in the male reproductive tract has become a real concern because of their potential toxic effects at high levels on sperm quality and function. The purpose of this study was to determine and compare the concentration of ROS in testicular homogenate of hyperprolactinemic adult male mice and their affect on sperm motility. Materials and Methods: 18 adult male mice were categorized in 3groups as control, sham and treatment. Hyperprolactinemia induction was administrated by 40mg/ kg/day Sulpiride atypical antipsychotic drug solution injection for 45days IP. Sham received placebo. After 45days couda epididymis were removed and placed in HTF medium. After sperm swimming up, the spermatozoal suspention was analyzed for sperm motility.Serum and testicular prolactin were measured in the plasma and testicular homogenate samples of all mice. Induction of oxidative stress ascertained by monitoring the degree of malondealdehyde(MDA) and total nitrite(NO)nm/grprotein of testicular homogenates. Results: Higher levels of prolactin plasma concentration and prolactine of tissue homogenate were found in treated group than control and sham groups(p< 0.05). Statistically significant decrease in sperm motility was found between treated group and 2other groups (p< 0.05). Additionally MDA and NO levels increased in testicular tissue by hyperprolactinemia. No significant differences were found between 2 other groups. Conclusion: Hyperprolactinemia by excessive production of ROS causes negative effects on male reproductive function. Oxidative stress-induced damage to sperm may be mediated by lipid peroxidation of the sperm plasma membrane and reduce sperm motility that increases fertility problems.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/811
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