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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۲۵-۲۵
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عنوان انگلیسی Ps-14: MRI Evaluation for Repairing Effects of Adipose-Derived Stem Cells on Cartilage Defects of Rabbit Knee Joints
چکیده انگلیسی مقاله Objective: There are limited treatment options for cartilage defects in clinical practice because of the lack of suitable bioMaterialss. Adipose stem cells (ASCs) are believed to be multipotent in differentiation into chondrogenic lineage. This study assessed the effectiveness of intra-articular injection of autologous ASCs to repair a full-thickness articular cartilage defect in the medial femoral condyle of rabbits to augment healing of defects. Materials and Methods: A full-thickness (without penetration of the subchondral bone, with 4 mm in diameter) cartilage defect was created in the medial femoral condyle of twelve adult Dutch rabbits. Allogeneic ASCs harvested from subcutaneous adipose tissue were injected intra-articularly after the creation of the defect. Defects without treatment were used as controls. The rabbits were sacrificed 4 and 8 weeks after surgery for MRI analysis using BLOKS scoring system. Results: The rabbit knee joints were underwent dynamic changes during the process of tissue repair in the defective area after operation. No statistically significant differences were detected between BLOKS scoring system characteristics of all the groups (p>0/05). Control groups showed a deal amount of intra-articular effusion with obvious peripheral tissue edema and a majority of bone marrow lesions. However, these characteristics were not present in treatment groups. Conclusion: The results showed that injection of ASCs prevent progression of lesions in treatment group whereas there were no repairing effects of ASCs in control group.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/819
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