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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۳۰-۳۰
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عنوان انگلیسی Ps-24: 1, 25-dihydroxyvitamin D3, As Proper Protector for Endothelial Cells in Multiple Sclerosis Patients
چکیده انگلیسی مقاله Objective: Previous publication reported that low-levels of vitamin D are associated with multiple sclerosis (MS). Thereby, strong evidence in MS pathogenesis suggests that endothelial cells (EC) could be harmed in MS. In addition, functional changes in EC and macrovascular injuries lead to blood-brain barrier (BBB) disruption in MS. Current study is the first investigation to elucidate positive influences of vitamin D on ECs surveillance in MS patients. Materials and Methods: Human umbilical vein endothelial cells (HUVECs) were cultured and then treated with sera from patients who had relapsing remitting MS history and sera from healthy volunteer participants as control group (each group n=15). MTS assay for cell surveillance and Cell Death Detection Kit for evaluating apoptosis were used in this study. Results: Vitamin D suppressed the induction of apoptosis by the serum of MS patients. This effect was significantly better when it was used before treating HUVECs with the sera of MS. The MTS results showed that preadministration of 10-7 M 1, 25 (OH)2 D3 significantly increased more ECs surveillances. Furthermore, the rate of apoptosis in different groups was assessed by Cell Death Detection Kit that detects inter-nucleosomal degradation of genomic DNA during apoptosis. Conclusion: Overall it could be concluded that not only vitamin D protects the ECs from apoptosis, also leads into ECs surveillances.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/829
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