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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۳۲-۳۲
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عنوان انگلیسی Ps-31: A Reduction in PGC1α Expression Triggered A Decrease in Fndc5 Expression Level in The Final Stage of Beating Body Formation of Mouse Embryonic Stem Cells
چکیده انگلیسی مقاله Objective: Fibronectin type III domain-containing 5 protein (Fndc5) encodes a membrane protein type 1. Previous studies by our group have shown that Fndc5 expression increased in forming beating bodies from mouse embryonic stem cells (mESCs), representing a novel function for this protein. On the other hand, Bostrom and colleagues identified PGC1α transcriptional coactivator expression induced Fndc5 expression in white adipose tissue (WAT) browning. Materials and Methods: To understand the relation between PGC1α and Fndc5, in first step expression pattern of PGC1α was investigated under distinct steps of cardiac differentiation by real-timePCR. Results: Data revealed an elevation in expression level of PGC1α when cardiomyocyte were formed. Thus correlation between PGC1α and Fndc5 was examined by application of a PPARγ antagonist (GW9662) that decreases PGC1α expression. Our results indicated that decreased PGC1α expression significantly reduced expression of Fndc5 in cardiomyocyte. Conclusion: These data confirm the correlation of Fndc5 and PGC1α in cardiogenesis which needs further verification.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/836
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