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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۳۵-۳۵
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عنوان انگلیسی Ps-35: Histological Study of Sciatic Nerve Repair after Transplantation of Human Umbilical Cord Matrix Stem Cell in Experimental Model of Transcected Sciatic Nerve in The Male Rat
چکیده انگلیسی مقاله Objective: Many researchers have focused on transplantation of pluripotent stem cells for repair of peripheral nerve injury. The umbilical cord matrix is rich source of mesenchymal stem cells that doesn’t stimulate immune system. The cells can be proper for treatment of nerve tissue injury. We examine the effects of HUMSC transplantation after transaction of sciatic nerve in rat by histological study. Materials and Methods: In this research, 30 adult male wistar rats (200-250 g) divide in to three groups randomly (n=10 in each group): A(control group) silicon tube, B(fibrin gel) silicon tube filled with fibrin gel without the cells, C(experimental group) silicon tube filled with fibrin gel seeded with HUMSC. In every group left sciatic nerve cut 10 mm and use 12 mm silicon tube as guide the nerve. In experimental group, HUMSC cultured and transplanted into tube. Eight weeks after the surgical procedure was assessed regeneration of sciatic nerve by histological study. Results: Histological assessment showed a significant difference between the experimental groups compared with other groups. Histological measures were significantly better in the HUMSC transplantation group compared with other groups (p< 0.05). Conclusion: Histological evaluation confirms that transplantation of HUMSCs improves repair of peripheral nerve injury.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/840
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