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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۳۷-۳۷
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عنوان انگلیسی Ps-40: Study of The Relation between rs11677451 and rs 2030259 Polymorphic Markers in Jhdm2a Gene and Male Infertility
چکیده انگلیسی مقاله Objective: JHDM2A is a histone demethylase that specifically demethylates mono- and di-methylated histone H3 lysine 9. JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A and KDM3A) is essential for spermatogenesis. JHDM2A also binds to and controls the expression of transition nuclear protein 1 (Tnp1) and protamine 1 (Prm1) genes, the products of which are required for packaging and condensation of sperm chromatin. Materials and Methods: Two Non-synonymous SNPs, rs11677451 and rs2030259 have been selected by Bioinformatics studies. Four primers were designed by using Oligo primer software. Genomic DNA was extracted from the blood of 50 control samples and 100 patients with azoospermia and oligozoospermia, then jhdm2a gene was amplified. Finally the samples analyzed by agarose gel. Results: So far we have observed bands in considered length due to designed primers, for patient and control samples, and its relationship with male infertility is under investigation. Conclusion: This study has focused on polymorphic markers of jhdm2a gene to evaluate its association with male infertility. The association reported in this study will be necessary to confidently validate these SNPs and identify novel SNPs associated with male infertility that can have therapeutic purposes.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/845
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