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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۳۹-۳۹
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عنوان انگلیسی Ps-45: Assessment of The Possibility of ERK1/2 Effect on Fndc5 Expression during Neural Differentiation of Mouse Embryonic Stem Cells
چکیده انگلیسی مقاله Objective: Fibronectin type III domain containing 5 protein (Fndc5) is a protein with unspecified role in neural differentiation. Early studies have indicated during neural differentiation of mouse embryonic stem cells (mESCs), Fndc5 expression enhanced specifically in neural precursor cells while Fndc5 knockdown, declined the neural differentiation efficiency suggesting a presumable role for Fndc5 in neural differentiation. To look further on the signaling pathway responsible for controlling Fndc5 expression during neural differentiation, MAPKs signaling pathways, which are a highway controlling most processes of differentiation were chosen to be studied. Materials and Methods: Fndc5 expression assessment was carried out by means of Real-time PCR and MAPKs activity was assessed by means of quantitative western blot. Results: The ERK1/2 MAPKs activity indicated a positive trend line correlation between the ERK1/2 activation and Fndc5 expression. Blockage of the ERK1/2 activation with respective specific inhibitor PD0325901 during neural differentiation, carried out to help us to assess whether it has an effect on Fndc5 expression. Conclusion: In case of a relationship, more strict and detailed studies should be carried out based on this result to find out the signaling pathway controlling Fndc5 expression because it may have importance in treatment of neurodegenerative disorders.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/850
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