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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۴۴-۴۴
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عنوان انگلیسی Ps-54: Investigation on Amount of Secreted Nitric Oxide from Endothelial Cells by Applying Shear Stress and Different Temperature
چکیده انگلیسی مقاله Objective: Endothelial cells (ECs), the inner layer of vascular wall, are constantly exposed to blood flow shear stress, which regulate important physiological blood vessel responses such as nitric oxide (NO) release. NO releases in response to the shocks such as shear stress and have some beneficial influence such as antithrombotic effect. This article aims to study the effects of temperature stress and combination of shear stress and temperature stress on ECs. Materials and Methods: By designing a perfusion bioreactor we applied shear stress to ECs cultured on the lumen of tubular silicone scaffold. We applied 25, 30, and 37°C and combination of these temperatures and shear stress to cells to study the amount of NO secretion. Results: Increase in shear stress and decrease in temperature leads to more increase in NO production than shear stress alone by folds of NO (p< 0.05). Conclusion: NO release by applying the shear stress is more than applying temperature alone. But our results show that to have the most NO release from ECs, applying 1.8 dyne/cm2 at 25°C is useful.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/858
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