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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۴۶-۴۶
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عنوان انگلیسی Ps-62: The Importance of Design and Heterologous Expression of Anti-Cancer Stem Cells Peptides As A Novel Paradigm for Cancer Treatment
چکیده انگلیسی مقاله Tissue stem cells form a small population of cells (usually much less than 1% within a given tissue), have selfrenewing potential and display significant plasticity. The capacity of stem cells for tissue renewal and damage repair has great potential applications for biotechnology, regenerative medicine and tissue engineering. However, they can pose a serious threat to the host organism if their differentiation potential becomes uncontrolled. Mutations within regulatory pathways can impair stem cell functions so that their high proliferative potential, and frequently their migratory capabilities as well, make these mutated stem cells tumorigenic. These tumorigenic stem/progenitor cell populations are collectively named CSCs. Anticancer drugs kill cancer cells and cause a reduction in tumor mass. Frequently, however, the cancer re-emerges after a few months or even years because the therapy failed to kill the CSCs. Cancer treatments that target CSC through specific markers or signaling pathways critically involved in CSC function could potentially increase the efficacy of current forms of therapy, by reducing the risk of relapse and dissemination. A6 is an 8-amino acid peptide that has been shown to have antiinvasive, anti-migratory, and anti-angiogenic activities. This peptide shares sequence homology with CD44, an adhesion receptor involved in metastasis that is also a marker of cancer stem cells, potentiated the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling. It seems that the designing peptides with strong stability followed by their heterologous (under vector) expression will provide a clear perspective in cancer treatment.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/866
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