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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۵۶-۵۶
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عنوان انگلیسی Ps-88: Endometrial Stem Cells Neuronal Differentiation Ability: A Perspective for Nerve Regeneration?
چکیده انگلیسی مقاله Objective: The human endometrium is a dynamic tissue, which undergoes cycles of growth and regression with each menstrual cycle. Endometrial regeneration also follows parturition and extensive resection and occurs in postmenopausal women taking estrogen replacement therapy. It was demonstrated that human endometrium contains a low number of endometrial stem cells (EnSCs) which seem to belong to the family of the mesenchymal stem cells (MSCs). Therefore, endometrium may be an alternative source of MSC-like cells for tissue engineering purposes, obtainable with no extra morbidity than that required for other sources of stem cells. The evidence that endometrial-derived stem cells were able to transdifferentiate into specialized cells of tissues different from endometrium, in particular into nervous cells, opened up the possibility of using endometrial-derived stem cells to substitute damaged neurons, that are normally not replaced but lost, in order to repair the Nervous System. Materials and Methods: The evidence that endometrialderived stem cells were able to transdifferentiate into specialized cells of tissues different from endometrium, in particular into nervous cells, opened up the possibility of using endometrial-derived stem cells to substitute damaged neurons, that are normally not replaced but lost, in order to repair the Nervous System. Results: Previous studies have shown EnSCs can respond to signalling molecules that are usually used as standards in neural differentiation and can programme cholinergic and dopaminergic neuronal cells. By inducing cholinergic neurons from EnSCs in a chemically defined medium, we could produce human neural cells without resorting to primary culture of neurons. This in vitro method provides an unlimited source of human neural cells and facilitates clinical applications of EnSCs for neurological diseases. Conclusion: In this review, we have examined the recent progress in this field, looking in particular at the applicability of human endometrial stem cells derived neurons usage to enhance nerve regeneration.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/892
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