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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۵۹-۵۹
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عنوان انگلیسی Ps-94: Combination of Final Blood Products Improves The Efficacy of Autologous Bone Marrow Stem Cell Therapy
چکیده انگلیسی مقاله Objective: Isolation procedures of autologous BMSCs might affect cell functionality and therapeutic efficacy. The aim of this study was to identify an association between combination of blood products and the quality and functional activity of bone marrow derived progenitor cells (BMCs) processed by special protocol and used for cardiovascular regenerative therapies. Materials and Methods: Quality of cell isolation was assessed by measuring the total number of isolated BMSCs, CD19+, CD34+ and CD45+ cells, their colonyforming unit (CFU) and invasion capacity, cell viability, and contamination of the final BMC preparation with thrombocytes and red blood cells (RBCs). Results: The number of final BMSC and the cell proliferation capacity significantly correlated with reduced isolation procedures, and a combination of autologous BMSCs with final blood products. Higher numbers of BMSC in the cell preparation were associated with increased BMSC viability, CFU capacity, and invasion potential. Conclusion: Combination treatment of autologous BMSCs affects the functionality of expanded BMSCs and determines the extent of their proliferation and their viability. These results suggest a bioactivity response relationship very much like a dose-response relationship in drug trials.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/898
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