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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۶۴-۶۴
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عنوان انگلیسی Ps-104: Expression Profile of CDH1 in Human Endometrial Tissue during The Menstrual Cycle
چکیده انگلیسی مقاله Objective: Endometrium is a specialized tissue that undergoes sequential phases of proliferative and secretory changes during the menstrual cycle, in order to support the implantation and growth of an embryo that are controlled by ovarian steroid hormones. Both estrogen and progesterone, through their receptors, stimulate the expression of key molecules in menstrual cycle, such as genes involved in cell adhesion events. Cadherins are major cell-cell adhesion molecules. E-cadherin is a transmembrane glycoprotein and exists as a cell-to-cell homophilic adhesion molecule at the adherens junction. In this study, the expression of E-cadherin coding gene (CDH1) has been evaluated in human endometrial tissue during menstrual cycle. Materials and Methods: Local ethical approval was gained for this study and informed consent was given by patients. All the women taking part in the investigation had regular cycles, showed no evidence of any pathological uterine disorder and had not used oral contraception or an intrauterine device in the previous 3 months. Cellular RNA was extracted from tissue samples and cDNA synthesis was performed on them. The expression level of CDH1 was evauated by the use of qRT-PCR techniqe. Results: There were some variations in mRNA expression of CDH1 gene in normal endometrium during menstrual cycle. Conclusion: This finding suggests the dynamic role of CDH1 in endometrium reconstruction during the menstrual cycle.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/908
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