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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۷۲-۷۲
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عنوان انگلیسی Ps-121: Expression of TGF-β RI and TGF-β RII Genes in Patients with Multiple Sclerosis following Vitamin D Supplementation
چکیده انگلیسی مقاله Objective: Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system characterized by chronic inflammation, demyelination, and axonal damage. Despite decades of research, the etiology and pathogenesis of MS is still unknown, though both genetic and environmental components of the disease seem evident. One potential environmental factor affecting the development of MS may be vitamin D [1,25-(OH)2D3]. A protective effect of vitamin D on multiple sclerosis is supported by the reduced risk associated with sun exposure and use of Vitamin D supplements. Moreover, high circulating levels of Vitamin D have been associated with lower risk of multiple sclerosis. Here we determined whether vitamin D supplementation of MS patients regulated several vitamin D targets. The effect of short-term vitamin D supplementation on selected anti-inflammatory cytokines was assessed in a group of MS patients. Materials and Methods: To test this hypothesis, Multiple sclerosis patients placed into a vitamin D supplemented group. Blood samples from 10 patients with MS before and 8 weeks after vitamin D therapy. Level of the TGF-β RI and TGF-β RII mRNA measured using Real Time PCR and the results compared. Results: mRNA levels of TGF-β RI and TGF-β RII increased following vitamin D supplementation. Conclusion: This is the first study to report the expression of the TGF-β RI and TGF-β RII genes in MS patients supplemented vitamin D. This study further implicates vitamin D as a strong environmental candidate in MS by demonstrating functional interaction with the effecting genes in MS.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/925
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