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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۷۴-۷۴
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عنوان انگلیسی Ps-123: Autofluorescence in Stem Cells and Augmentation of Regeneration Kinetics by Riboflavin
چکیده انگلیسی مقاله Objective: The objective of this study is to find stem cell niche, the characterization of stem cells and to find stem cell and regenerative medicine. Materials and Methods: Culture and maintenance of earthworm, Autofluorescence of coelomic fluid cells, histology, thin-layer chromatography, BrdU labeling retention assay, mmunohistochemistry. Results: The earthworm has significant amount of riboflavin in its body. The riboflavin concentration is seven fold higher in the stem cells which resides in the skin of the earthworm. The cells migrates to the amputation sites and proliferates more upon the amputation. The rich amount of riboflavin in the stem cell provide the beautiful fluorescent property to the stem cells. The riboflavin supplementation augments the regeneration and stem cell proliferation. The worm receives riboflavin from the gut microflora. Conclusion: The earthworm which has more riboflavin in its body has strong regeneration capacity and similarly, the liver which has strong regenerating potential, has higher concentration of the riboflavin than any other organs in the mammals. In addition, the human skin stem cells also has the auto-fluorescent property. The data suggest that the fluorescent property of stem cell is conserved from human to the annelids. The finding of riboflavin as regeneration augmenter will help to use the riboflavin for the regenerative medicine.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/927
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