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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۷۶-۷۶
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عنوان انگلیسی Ps-129: Expression Alteration of miR-2276 in Tissue Samples Obtained from Patients with Breast Cancer
چکیده انگلیسی مقاله Objective: Breast cancer is one of the most common malignancies in women. It continues to be a major burden and cause of death among women worldwide. Most patients die of distant metastases that are frequently unresponsive to cancer therapy. In order to metastasize, cells need to be able to migrate and invade into the surrounding tissue, intravasate in to a blood vessel or lymphatic system, survive in circulation, extravasate and finally proliferate at a distant site. Piwi (P-element-induced wimpy testis) is a subgroup of the Argonaute proteins. The genes of the piwi family are defined by conserved PAZ and Piwi domains and play important roles in stemcell self-renewal, RNA silencing and translational regulation in various organisms. MicroRNAs (miRNAs) are small noncoding RNAs (19 to 24 nucleotides) with regulatory functions, which play an important role in breast cancer. miRNAs can act either as tumor suppressors or as oncogenes, and that measurement of miRNA expression in malignancies may have diagnostic and prognostic implications. Although miR-2276 is target Piwil2 gene and Piwil2 role in stem-cell self-renewal, the molecular pathway of Piwil2 in breast cancer and its role in proliferation of breast cancer cells .This study was designed to evaluate the expression alterations of miR-2276 in breast cancer tissue samples. Materials and Methods: Total RNA was extracted from paraffinated-tissue breast cancer samples using trizol. Afterward, cDNA synthesis and Real time-PCR assay were performed by specific stem-loop primers. Results: Results of our study, up to now, demonstrated significant changes of miR-2276 expression in tumor samples in comparison with non-tumor samples. Conclusion: Considering previous and related studies, mir-2276 may have important role in breast cancer pathogenesis among susceptible women. Therefore, this miRNA can be applied as a breast cancer marker in diagnostic and prognostic tests.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/931
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