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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۷۷-۷۷
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عنوان انگلیسی Ps-132: Biomarkers of Endocrine Disruption: Cluster Analysis of Effects of Plasticisers on Phase 1 and Phase 2 Metabolism of Steroids
چکیده انگلیسی مقاله Objective: Endocrine disrupters (EDs) are environmental compounds which affect steroid synthesis or steroid metabolism and so alter physiological responses. The objective was to design a profile of in vitro tests to identify EDs so that safer industrial compounds could be introduced and much animal testing avoided. Materials and Methods: Plasticisers, including phthalates, alkyl phenols, adipates and other phenols were selected as known EDs and 16 of these compounds were assayed in 23 different tests for steroid metabolism, steroid nuclear receptor action, cell signalling, thyroid metabolism Results: The matrix of results was analysed by cluster analysis. This showed that 4 of the 23 assays were particularly informative. EDs altered the activity of SULT 1E1, a sulphotransferase enzyme which inactivates oestrogens by sulphation, the provision of inorganic sulphate for oestrogen sulphation, the activity of aromatase for oestrogen synthesis and thyroid metabolism Conclusion: Both genomic and non-genomic effects of EDs are important. A profile of rapid robust in vitro tests to identify EDs was produced and the ranking on this test was in accordance with the known ED effects of the compounds tested.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/934
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