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Cell Journal، جلد ۱۵، شماره Suppl ۱، صفحات ۷۹-۷۹
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عنوان انگلیسی Ps-136: The Potential of Stem Cells in Fetal Therapy
چکیده انگلیسی مقاله Objective: Over last years, extensive efforts have been made to find new ways for treatment of congenital diseases. One of the most relying approaches is fetal therapy. During embryonic development, organ development will not be completed. Thus, it is an opportunity to treat some congenital diseases before termination of organ development. As regards organ development did not complete in embryonic development, it seems that we can treat some congenital diseases before finishing development of organs. Materials and Methods: Search of the literature published in English using the PubMed database, intellectual comparison and deduction. Results: Fetal therapy contains all of works -medical or surgical- that performed for treatment of sick fetus. In this study, new approaches of regenerative medicine combined to fetal therapy. Recapitulation, stem cell therapy and gene therapy may help developing of fetal therapy as a new way for treatment of congenital diseases. Furthermore, these subjects combined and discussed as a new approaches of fetal therapy. Conclusion: Prenatal diagnosis of congenital diseases can lead to the diagnosis of severe fetal abnormalities. Fetal therapy can be alternated to terminate pregnancy in abnormal fetuses. Fetal gene therapy using stem cells (e.g. hematopoietic stem cell) is a promising new approach. Future development of this technique needs safe protocols and preclinical investigations on animals prior clinical trials in human fetuses. Although fetal therapy may open new horizons for treatment of several diseases, there are major ethical aspects needs to be considered.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/938
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