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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-15: Homocysteine Intrahippocampal injection-Increased MDA and SOA Levels as Well as Impaired Memory Retention in Rats
چکیده انگلیسی مقاله of Methionine and its increased level in plasma, called Hyperhomocysteinemia .Recently the role of Homocysteine in some neurodegenerative diseases for example Alzheimer’s disease was investigated in some studies. In this study we investigated the effect of Homocysteine (Hcy) on oxidative stress in rat’s hippocampus. Materials and Methods: Hcy was injected (0.2 micromoles) intrahippocampal in rats . Two parameters of oxidative stress, Malondy Aldehydes (MDA) and Super Oxide Anion (SOA) were analyzed with spectrophotometer .On the other hand the effect of Hcy on the Memory was studied by Passive Avoidance Learning Apparatus. Results: Results indicated that Hcy induced lipid peroxidation and increased malondialdehyde (MDA) and superoxide anion (SOA) levels significantly (p< 0.05) in the hippocampus. In addition, Hcy impaired memory retention in the passive avoidance learning test. Conclusion: These results suggest that Hcy may induce lipid peroxidation in hippocampus as well as impaired memory retention. Studies in the future will reveal the role of this toxic metabolite in the pathophysiology of some neurodegenerative diseases such as Alzheimer’s disease.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1547
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