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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-18: IFNγ Receptor Mutation in the TBPatient’s PBMC
چکیده انگلیسی مقاله Objective: Tuberculosis is the most important disease in the world that leads to the death of approximately 2 million people every year. IFNγ/IFNγR1 are the most important genes that are associated with tuberculosis. In this study, we investigated the single nucleotide polymorphism in IFNγR1 gene and its influence on patients with tuberculosis in the North of IRAN. Materials and Methods: The case-control study consisted of 62 patients with TB and 74 controls that all patients had no HIV infection. PBMCs were isolated from two groups and genomic DNA was extracted by DNA isolation kit. PCR products were digested by 2U of restriction enzymes. Then, RFLP-PCR digested products were detected by gel electrophoresis. Results: The frequency of -56C/T SNP mutation in the patients with Tuberculosis was 64% and this frequency in the control group was 25%. We found that -56C/T SNP was associated with clinical outcome of Tuberculosis infection (p=0/033). Conclusion: Our data implied the involvement of the -56C/T SNP inIFNγR1 promoter association with the susceptibility to tuberculosis.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1550
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