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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-23: Repair of Spinal Cord Injury (SCI) Using Bone Marrow Stromal Cell Transfected with Adenoviral Vector Expressing Glial Derived Neurotrophic Factor (GDNF) in a Rat SCI Model
چکیده انگلیسی مقاله Objective: Subsequent to spinal cord injury many pathological changes may occur that lead to inappropriate environment for repair, most important of which is the death of neurons. Exogenous administration of growth factors that modulate neuronal survival, synaptic plasticity, and neuro-transmission has been proposed as a potential therapeutic treatment for SCI. Among these growth factors, GDNF is a peptide with pleiotropic survival and growth-promoting effects on neurons. In addition, GDNF induces the growth of motor and sensory axons and inhibits neuronal apoptosis. Adult stem cells may provide new strategies to treat SCI. Among various types of candidate stem cells, the bone marrow stromal cell (BMSC) is promising because it has shown potential to neuronal differentiation and repair damaged spinal cord. In this study we tried to Cell Journal(Yakhteh), Vol 13, Suppl 2, Spring 2011 35 Abstracts of the 2nd National and 1st Int. Congress on "Cellular and Molecular Advances in Non-Contagious Diseases" improve results of treatment using combination of BMSC and GDNF features. Materials and Methods: Rats were divided into four groups of six at random. Spinal cord injury was then performed under general anaesthesia using the weight dropping method. The cells were injected at 4 days postspinal cord injury. Group one included rats receiving normal saline, group two received BMSC, group three received BMSC infected with adenoviruses encoding the beta-galactosidase gene, and group four received BMSC infected with adenoviruses encoding the GDNF gene. A Basso, Beattie and Bresnahan (BBB) score test was performed for four weeks. Two weeks before the end, biotin dextran amine was injected intra cerebrally and at the end of the fourth week tissue staining was performed. Results: There was a significant difference in BBB scores between groups one and four. There were no significant differences between other groups. Conclusion: Combined use of these methods (GDNF expressing BMSCs) had better results in comparison with BMSC alone. In this study the two methods were used simultaneously. The time of injection of BMSCs is very important and so we suggest that other injection times be tested
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1555
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