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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-34: A Comparison Study of Expression of Desmin, Vimentin and Cytokeratin in Canine, Human and Rodent Sertoli Cell Tumor and Normal Testicular Tissue by Imunohistochemictry
چکیده انگلیسی مقاله Objective: Sertoli cell tumor (SCT) is common in dogs, affecting mainly old or cryptorchid animals. During maturation from fetal to adult testis, SCs undergo a process of differentiation whereby the expression of some cytoskeletal markers is maintained, while other markers disappear and others are acquired. Human fetal Sertoli cells (SCs) have shown transient expression of cytokeratin (CK) and desmin (DES) that is replaced after birth by expression of vimentin (VIM). Human Sertoli cell tumours (SCTs) are characterized by re-expression of CK and DES. Materials and Methods: Neoplastic Samples from mature dogs (n=14) and Normal testicular tissue from two adult dogs, one 6-month-old puppy and two neonatal pups were obtained. For each sample, sections (5 μm) were stained with haematoxylin and eosin (HE) and Immunohistochemical labelling was performed using the avidin-biotinperoxidase complex (ABC) procedure. Results: VIM was expressed in the stroma of all testes examined. Samples those from adult and puppy expressed VIM, while those of neonates were negative. All SCTs strongly expressed VIM. SCs did not express CK and DES. But were expressed only by some SCTs. Conclusion: The SCs of adult dogs expressed VIM, confirming that expression of this molecule may be reliable marker for dogs. Canine SCs do not express VIM at the time of birth but man and rodent, SCs express VIM before birth . SCs in dogs did not express DES and CK. This result is similar to in man and rodents, where only transient expression of these proteins in early fetal stages and is lost in the early phases of gestation, so expression of these molecules by canine SCTs may be because of neoplastic regressing of canine SCs to an undifferentiated immunophenotype. Thus Canine SCTs may express CK and DES, suggesting that the neoplastic cells undergo de-differentiation during transformation.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1566
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